Figure 6
From: Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme
NIM811 activates both CD and CI translation. (a-c) CD and CI translation were measured by the dual renilla/firefly luciferase assay after 24 or 48 h of indicated treatments, and relative light units were normalized to cell numbers. NIM811 significantly increased the CI and CD translation at 10 and 15 μM, *P<0.05. (d-f) Pretreatment of rapamycin, torin-2 effectively decreased CD translation during NIM811 incubation, whereas brief pretreatment with cycloheximide substantially decreased both CD and CI translation. *P<0.05
