Figure 1 | Cell Death & Disease

Figure 1

From: Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways

Figure 1

CRNDE expression is upregulated in CRC and could be an independent prognostic factor for the prediction of the overall survival of CRC patients. (A) Expression levels of CRNDE in paired CRC and adjacent non-cancerous tissues. (B) Expression levels of CRNDE in CRC and colon mucosa epithelial (NCM460) cell lines. (C) Expression analysis of CRNDE in normal colorectal mucosa and CRC tissues by ISH. (a) Negative expression of CRNDE in normal colorectal mucosa. (b) High expression of CRNDE in a tumor tissue sample and weak expression of CRNDE in its normal mucosal counterpart were observed in one filed of a tissue sample from a single patient. (c) High expression of CRNDE in CRC tissue. Scale bars are shown in the lower right corner of each picture. (d) Graphical illustration of statistical CRNDE distribution in CRC patients. (E) Kaplan–Meier analysis of overall survival in all patients with CRC according to CRNDE expression. *P<0.05

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