Figure 5 | Cell Death & Disease

Figure 5

From: Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

Figure 5

Effect of Pb on protein levels of three V-ATPase subunits in isolated lysosomes of rPT cells. Cells were treated with Pb (0.25, 0.5 and 1 μM) for 12 h, then fractionated into the lysosomal lysis to assess the protein levels of ATP6V1A (a), ATP6V1B1+ATP6V1B2 (b) and ATP6V1D (c). Upper panels represent western blot images; lower panels represent quantitative analysis of protein levels (mean±S.E.M., n=4). ns, not significant, *P<0.05, **P<0.01, as compared with control

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