Figure 8 | Cell Death & Disease

Figure 8

From: Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

Figure 8

Evaluation of BRCA2 disruption-associated transcriptional phenotype with transcriptional patterns of clinical samples. (a) Heat map showing expression of transcripts relating to dominating transcriptional network modules delineated in gene expression data of bone marrow samples from FA patients compared with unaffected controls as GEO data set GSE16334.21 (b) Analysis of these transcripts in FA-derived MMC sensitive SB1690CB cells and their resistant SBRes progeny. (c) Heat map showing BRCA disruption-associated genes in clinical ovarian cancer6 in sensitive SB1690CB Cells compared with their resistant SBRes progeny. Significantly differentially expressed transcripts framed in yellow boxes

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