Figure 8
From: EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy
Proposed model of EGR-1/ASPP1 inter-regulatory loop in promoting apoptosis. Upon various stimuli, such as anticancer natural compound Quercetin, EGR-1 is activated, which binds with EBS localized at ASPP1 promoter region and then transactivates ASPP1 expression in the nucleus. Elevated ASPP1 is mainly localized at cytoplasm, which, in turn, inhibits proteasome-mediated EGR-1 degradation and also promotes EGR-1 nuclear import. Activated EGR-1 can further promote apoptosis by transactivating its pro-apoptosis targets, including EGR-1 itself. Meanwhile, ASPP1 binds with Atg5–Atg12 and inhibits their conjugation and further complex formation with Atg16, leading to cyto-protective autophagy inhibition and apoptosis induction
