Figure 8 | Cell Death & Disease

Figure 8

From: Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex

Figure 8

Reciprocal relationship of Cdc20 and SMAR1 in breast cancer. (a) Expression of SMAR1 shares an inverse correlation with Cdc20 in higher grades of breast cancer cell lines. (MCF 10A: Primary breast epithelial cell line, MDA-MB-435: Basal B and BT 549: Basal B tripe negative breast cancer cell line, rest of the cell line information given in Supplementary Figure 1a).22, 23, 24 (b) Expression level of SMAR1 (upper panel) and Cdc20 (lower panel) in normal and higher grades of breast cancer patient samples. Tissues were stained for immunohistochemical analysis as described in the Materials and Methods. (c) Statistical analysis of the average score of SMAR1 and Cdc20 staining between cancer tissues and corresponding non-tumor tissues, P<0.0001 (one-way ANOVA). (d) Model depicting the regulation of SMAR1 in normal and genotoxic stress conditions by APC/CCdc20

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