Figure 7 | Cell Death & Disease

Figure 7

From: Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming

Figure 7

FAM210B knockdown was co-induced with an EMT program. Normalized OCR (a) and (b) scale bar of basal OCR and maximum OCR in the indicated cells (n=4). (c) Normalized ECAR and (d) scale bar of basal ECAR and maximum ECAR in the indicated cells (n=4). (e and f) Crystal violet-stained SKOV3 with different treatments. (g) KEGG pathway microarray analysis of different pathways in siFAM210B compared with the negative control. (h) mRNA expression of E-cadherin, N-cadherin, Vimentin, and FN1 in siFAM210B and siPDK4 cells versus control. (i) Protein expression of E-cadherin and Vimentin in the indicated cells. Data were represented as the means±S.E.M. NS: not significant. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001

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