Figure 7
From: Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes
Aβ1–42 increases ROS formation from NADPH oxidase. (a) Representative CellROX images of astrocytes under control conditions, or following a 24 h treatment with 100 nM Aβ1–42 alone, or together with GKT137831 (10 μM), or CORM-2 (20 μM) or iCORM (20 μM), as indicated. Bottom right image shows the effects of 20 μM CORM-2 alone. All images also show DAPI (nuclear) staining. Scale bar applies to all images. (B) Mean±S.E.M. fluorescence determined under the conditions exemplified in a. Data taken from 10 regions of interest, measured in 3–5 images from 3 experimental repeats. Significance: ***P<0.001 as compared with control or compared with 100 nM Aβ1–42 treatment, as indicated
