Figure 1 | Cell Death & Disease

Figure 1

From: Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

Figure 1

Efficiency of lentivirus transfection in ApoE−/− mice. (a) Flow charts showing the experimental protocol used in the in vivo studies. (b) Fluorescence images of the aortic root and carotid plaques two weeks after lentivirus transfection in the lenti-GFP group. (c,d) DKK1 protein expression in the aortic root in four groups of mice as determined by Western blotting. n=6. (e) Areas stained positive for DKK1 in four groups of mice as determined by immunohistochemical staining in the aortic root and carotid plaques. n=6. (f) Plasma levels of DKK1 in four groups of mice. (n=11). (g) Co-localization of DKK1 (red) and endomucin (green) or MOMA-2 (green) expression in aortic plaques in the NS group. DAPI (blue) indicates nuclei. Data are shown as the mean±S.D., *P<0.05 versus NS; #P<0.05 versus GFP

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