Figure 2 | Cell Death & Disease

Figure 2

From: Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

Figure 2

Influence of DKK1 on plaque formation and stability in ApoE−/− mice. (a) En face Oil Red O staining of aortas and cross-sectional aortic root lesions with H&E staining in four groups of mice (NS, GFP, shDKK1, and DKK1). (b) Quantitative analysis of en face aortic lesions expressed as percentage lesion area relative to total aorta area. n=6. (c). Quantitative analysis of cross-sectional plaque areas in aortic roots. n=6. (d–e,h–i) Representative immunohistochemical staining and quantification of plaque content in aortic plaques and carotid artery plaques. n=6. (f,j) Quantitative analysis of plaque vulnerability indices of the aortic plaques and carotid artery plaques. (g) Quantitative analysis of plaque fibrotic cap thickness of aortic plaques. n=5. (k) Quantitative analysis of plaque area and total lumen area in the carotid artery. n=6.Data are shown as the mean±S.D. *P<0.05 versus NS; #P<0.05 versus GFP

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