Figure 3 | Cell Death & Disease

Figure 3

From: Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

Figure 3

Effects of DKK1 on inflammatory factors and plaque apoptosis in ApoE−/−. (a) Representative immunohistochemical staining and quantification of plaque content of inflammatory factors (IL-6, IL-1β, MCP-1, and TNF-α). n=6. (b) Representative immunohistochemical stained images and quantification of Bax, Bcl-2, cleaved caspase-3 and caspase-12 levels in atherosclerotic plaques of ApoE−/− mice. n=6. (c) Co-localization and quantitative analysis of TUNEL staining (green) and endomucin-positive areas (red) to measure cellular apoptosis in aortic plaque. DAPI (blue) indicates nuclei. n=3. Data are shown as the mean±S.D., *P<0.05 versus NS; #P<0.05 versus GFP

Back to article page