Figure 5 | Cell Death & Disease

Figure 5

From: Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

Figure 5

Impact of long-term fenofibrate administration on brain UCP2 modulation, NF-κB protein expression, oxidative stress and stroke occurrence in JD-fed SHRSP. (a) UCP2 expression is shown in SHRSP fed for 4 weeks with RD (n=7), JD (n=7), JD plus vehicle (n=4) and at the end of three months of JD plus fenofibrate treatment (n=6). ***P<0.0001 for each comparison. (b) WB of UCP2 expression in the four experimental groups as above with corresponding densitometric analysis. ***P<0.0001 for each comparison. (c) WB of NF-κB expression in the four experimental groups as above with corresponding densitometric analysis. ***P<0.0001 for each comparison. (d) WB of carbonylated total proteins in the four experimental groups with corresponding densitometric analysis (e). See legend of Figure 2b, for the WB of carbonylated total proteins. ***P<0.0001 for JD versus RD fed SHRSP; **P<0.001 for JD plus fenofibrate versus JD plus CMC fed SHRSP. (f) Stroke survival rate in the JD, JD plus vehicle and JD plus fenofibrate treated SHRSP. The comparison of JD plus fenofibrate treated SHRSP versus both JD and JD plus vehicle treated SHRSP was significant, P<0.001

Back to article page