Figure 6 | Cell Death & Disease

Figure 6

From: Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

Figure 6

Impact of long-term administration of BO on brain UCP2 modulation, NF-κB protein expression, oxidative stress levels and on stroke occurrence in JD-fed SHRSP. (a) UCP2 expression is shown in SHRSP fed for 4 weeks with RD (n=7), JD (n=7) and in SHRSP receiving both JD plus BO at times of stroke occurrence (8 weeks of treatment, n=2; 10 weeks, n=2; 12 weeks, n=3), SHRSP receiving JD plus BO plus PPARα inhibitor (7 weeks of treatment, n=4; 8 weeks of treatment, n=1). ***P<0.0001 for each comparison. (b) WB of UCP2 protein expression in the four experimental groups as above with corresponding densitometric analysis. ***P<0.0001 for each comparison. (c) WB of NF-κB protein expression in the four experimental groups as above with corresponding densitometric analysis. ***P<0.0001 for each comparison. (d) WB of carbonylated total proteins in the four experimental groups. See legend of Figure 2b, for the WB of carbonylated total proteins. (e) Stroke survival rate in the JD, JD plus BO, JD plus BO plus PPARα inhibitor treated SHRSP. The comparison of JD plus BO treated SHRSP versus both JD and JD plus BO plus PPARα inhibitor treated SHRSP was significant, P<0.001 and P<0.001, respectively

Back to article page