Figure 3 | Cell Death & Disease

Figure 3

From: Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

Figure 3

Alleviated renal fibrosis in mice with established nephropathy after IL-22 gene therapy. (a) Renal expression of fibronectin, collagen IV, vimentin, and α-SMA by immunoblot analysis. (b) Quantitative analysis of renal expression of fibronectin, collagen IV, vimentin, and α-SMA from three individual experiments. (c) Deposition of the ECM proteins including fibronectin and collagen IV in glomeruli by immunohistochemistry analysis. Original magnification: × 400. (d) Qualification of glomerular fibronectin and collagen IV expression by ImageJ. Densitometric values of immunoreactive bands were normalized to those of β-actin and the results were expressed as fold changes. **P<0.01

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