Figure 6
XIAP depletion in tumor cells promotes lung colonization of mice in a Cdc42-dependent manner (a) NOD-SCID mice were injected through the tail vein with 1 million tumor cells treated with different siRNAs as indicated. Mice were killed after 4–5 weeks of injection and the lungs were isolated. Shown are pictures of the whole lung (b) Metastatic nodules were counted manually on each lung by three independent pairs of eyes, with five mice lungs counted per condition (c) Lungs were fixed and H&E-stained and representative images of the lungs are shown. (d) Proposed model for the interaction between XIAP and Cdc42
