Figure 6

CALCB mutation effect the phosphorylation of ERK1/2. Phosphorylation of AKT1 on serine 473 (pAKT1, S473), total AKT1 protein. Phosphorylation of ERK1/2 (phospho-T202/204) and total ERK1/2 protein. GAPDH levels were assessed as a control for loading