Figure 1

MIAT knockdown improves cardiac structure and function in diabetic rats. (a) The expression of MIAT in myocardium was detected by real-time PCR. (b–e) Left ventricular structure and function were assessed by echocardiography. (f,g) The expression of miR-22-3p and DAPK2 was analyzed by real-time PCR and western blot. *P<0.05 compared with control; #P<0.05 compared with DM+Scr-shRNA (n=5 per group)