Figure 3 | Cell Death & Disease

Figure 3

From: lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy

Figure 3

MIAT is involved in the regulation of high glucose-induced apoptosis. (a) Cardiomyocytes were transfected with adenoviral MIAT-siRNA or Scr-siRNA and then exposed to high glucose (HG, 30 mmol/l) for 48 h. The expression of MIAT and miR-22-3p was measured by real-time PCR. (b,c) Cardiomyocytes were stained with Annexin V/PI and then subjected to flow cytometry to detect apoptosis. (d) The expression of apoptosis-regulatory proteins was determined by Western blot. *P<0.05 compared with control; #P<0.05 compared with HG+Scr-siRNA (n=5 per group)

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