Figure 6
From: Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis
AHR activation induced by FICZ and Glyteer restores FLG expression via OVOL1 in the skin affected by atopic dermatitis (AD). 1. FICZ and Glyteer bind to AHR thereby leading to AHR activation. 2. Activated AHR induces upregulation and nuclear translocation of OVOL1. 3. The OVOL1 nuclear translocation of OVOL1 increases FLG expression. 4. IL-4 inhibits the nuclear translocation of OVOL1. 5. Inhibition of the nuclear translocation of OVOL1 downregulates FLG
