Figure 6 | Cell Death & Disease

Figure 6

From: MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial–mesenchymal transition progression in bladder cancer

Figure 6

miR-323a-3p-mediated regulatory circuit in BCa. (a) The schematic diagram represented above includes miR-323a-3p/MET/SMAD3/SNAIL circuit, mutual regulation between three miRNAs (miR-323-3p, miR-433 and miR-409) and MET, and the dysregulation of miR-323a-3p induced by the methylation of DMR. (b–e) The mutual regulation between miR-323a-3p/miR-433/miR-409 and MET; however, SMAD3 may not reduce the level of miR-323a-3p. (f) Western blot analysis confirmed SMAD3 may not induce the expression of MET. Error bars represent the S.E. obtained from three independent experiments; *P<0.05

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