Figure 1 | Cell Death & Disease

Figure 1

From: Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

Figure 1

Effect of rKlotho administration on Tac-induced tubulointerstitial fibrosis in an experimental mouse model. (a and b) Histological analysis in the renal cortex in mice treated with Tac for 4 weeks showed striped tubulointerstitial fibrosis, mononuclear cell infiltration, and tubular atrophy. rKlotho treatment significantly reduced these damages compared with Tac treatment. Scale bar=100 μm. The data are presented as the mean±S.E. @P<0.05 versus the Tac group

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