Figure 2 | Cell Death & Disease

Figure 2

From: Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

Figure 2

Effect of rKlotho administration on Tac-induced oxidative stress and apoptosis in an experimental mouse model. Representative images and quantification of immunohistochemistry for 8-OHdG (a–d and n) and 4-HHE (e–h and o) and TUNEL assays (i–l and p), using tissue sections from mouse kidneys. High immunoreactivity was significantly decreased by the co-administration of rKlotho. (m) Urinary 8-OHdG excretion per day. Tac-induced 8-OHdG excretion was lowered by rKlotho co-administration. The arrows indicate 8-OHdG, 4-HHE, and TUNEL-positives. Scale bar=50 μm. The data are presented as the mean±S.E. #P<0.05 versus the VH group; $P<0.05 versus the rKlotho groups; @P<0.05 versus the Tac group

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