Figure 4 | Cell Death & Disease

Figure 4

From: Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

Figure 4

Klotho-induced MnSOD mRNA expression by regulating the PI3K/AKT/FoxO3a pathway in an experimental mouse model. Representative immunofluorescence images of phosphorylated AKT (p-AKT, a–d) and total FoxO3a (t-FoxO3a, e–h), and in situ hybridization of MnSOD mRNA (i–l) in tissue sections from mouse kidneys. Arrowheads point to nuclear punctate expression of t-FoxO3a in the Tac+rKlotho group. Asterisks indicate proximal tubules. Scale bars=20 μm (a–h) or 5 μm (i–l)

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