Figure 4 | Cell Death & Disease

Figure 4

From: MiR-30c regulates cisplatin-induced apoptosis of renal tubular epithelial cells by targeting Bnip3L and Hspa5

Figure 4Figure 4

Bioinformatics predicted the four potential target genes in cisplatin-induced renal tubule injury. (a) TargetScan was used to predict the potential target genes of miR-30c, and four target genes (Adrb1, Bnip3L, Hspa5 and MAP3K12) were found to be upregulated in cisplatin-treated HK-2 cells according to the CEO database (GSE69644). (b) The bar chart showing the quantitative PCR data on the mRNA expression levels of Adrb1, Bnip3L, Hspa5 and MAP3K12 in HK-2 cells of control and 48 and 72 h cisplatin-treated groups. (c) The bar chart showing the quantitative PCR data on the mRNA expression levels of Adrb1, Bnip3L, Hspa5 and MAP3K12 in the rat renal tissue of the control and the 1-, 3- and 7-day cisplatin-treated groups. Data represent the mean of three independent experiments±S.E.M. with n=3. *P<0.05; **P<0.01; ***P<0.001

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