Figure 2 | Cell Death & Disease

Figure 2

From: Increased tumor-infiltrating CD45RA−CCR7− regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress

Figure 2

Tumor-derived TNF-α induces CD45RA−CCR7− Treg subset. (a) Dot plots and statistics analysis of CD45RA−CCR7+ and CD45RA−CCR7− Treg subsets after Tregs exposed to autologous TTCS and NTCS for 24 h. (b) TNF-α concentration between autologous tumor and non-tumor tissues (n=18) was analyzed. The correlations between TNF-α and CD45RA−CCR7− or CD45RA−CCR7+ Treg subsets in GC were analyzed (n=50). (c–e) Dot plots and statistics analysis of CD45RA−CCR7+ and CD45RA−CCR7− Treg subsets after Tregs exposed to TNF-α (c), or after Tregs exposed to TTCS with anti-TNF-α antibody (d), or after Tregs exposed to NTCS with TNF-α (e) for 24 h. Each dot in panel b represents one patient. *, P<0.05; **, P<0.01, and n.s., P>0.05 for groups connected by horizontal lines

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