Figure 3 | Cell Death & Disease

Figure 3

From: Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism

Figure 3

Involvement of the AMPK/AKT/GSK3β pathway in Nrf2 nuclear translocation by Betulin. Cells were treated with 3 μM compound C (Comp.C) for 18 h before treatment with betulin (36 μM) for 6 h. Cell lysates were immunoblotted for the phosphorylation of AMPK, Akt, GSK3β and Nrf2. A representative western blot is shown in the left panel. Shown in the right panel are means±S.E.M. of three independent experiments. **P≤0.01 versus the control group; ##P≤0.01 versus the betulin group

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