Figure 4 | Cell Death & Disease

Figure 4

From: RETRACTED ARTICLE: Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β

Figure 4

Dioscin activated ERβ signaling pathway in PC3 cells and mammospheres. (a) Effects of dioscin (1.4, 2.8 and 5.6 μM) for 24 h on ERβ, PHD2, HIF-1α and VEGF-A expression levels in PC3 cells. (b) Effects of dioscin (2.5, 5.0 and 10.0 μM) for 24 h on ERβ, PHD2, HIF-1α and VEGF-A expression levels in PC3 cell-derived mammospheres. (c) Effect of dioscin (1.4, 2.8 and 5.6 μM) for 24 h on BMI-1 protein expression in PC3 cells. (d) Effect of dioscin (2.5, 5.0 and 10.0 μM) for 24 h on BMI-1 protein expression in PC3 cell-derived mammospheres. Data are presented as the mean±S.D. (n=5). *P<0.05 and **P<0.01 versus Control group

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