Figure 8

Dioscin activated ERβ signaling in vivo. (a) Effects of dioscin and ERβ-siRNA on cleaved caspase-3, cleaved PARP, Bax and Bcl-2 expression levels in tumor tissue. (b) Effects of dioscin and ERβ-siRNA on ERβ, PHD2, HIF-1α, VEGF-A and BMI-1 expression levels in tumor tissue. Data are presented as the mean±S.D. (n=5). *P<0.05 and **P<0.01 versus Control group; NS, not significant