Figure 2 | Cell Death & Disease

Figure 2

From: Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

Figure 2

Amlexanox induced G0/G1 phase arrest and apoptosis in glioma cells. (a) U87 and U251 cells were treated with various concentrations of amlexanox for 72 h and then, assessed by propidium iodide staining-coupled flow cytometry. (b) Bar graphs showing a concentration-dependent cell cycle arresting effect of amlexanox in U87 and U251 cells. (c) After treatment with various concentrations of amlexanox for 72 h, U87 and U251 cells were stained with annexin V-FITC and PI for analysis using flow cytometry. (d) Increased apoptotic cells in U87 and U251 were quantified and presented in the histogram. Data are shown as the mean±S.D. n=3 for each group. *P<0.05 and **P<0.01 compared with the control group

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