Figure 7 | Cell Death & Disease

Figure 7

From: Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

Figure 7

Amlexanox exhibited significant antitumor effects against subcutaneous tumors in vivo. (a) Images of nude mice and tumors from the DMSO and amlexanox treatment groups. (b) The tumor volumes and (c) weights, and (d) the body weights of mice were evaluated using the in vivo proliferation assay. (e) Representative images of the HE and immunohistochemical staining for IKBKE and the proteins of the Hippo pathway in tumor sections (× 200 magnification). IKBKE protein was effectively inhibited by amlexanox treatment. Besides, the expressions of LATS2 and p-YAP1(Ser127) increased, whereas YAP1, Axl, c-Myc, Cyr61, MMP-2 and MMP-9 expression levels were simultaneously decreased in amlexanox-treated group relative to the DMSO-treated group. Data are shown as the mean±S.D. *P<0.05, **P<0.01, compared to the control (n=6)

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