Figure 8 | Cell Death & Disease

Figure 8

From: Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

Figure 8

Antitumor effects of amlexanox in a U87 orthotopic intracranial model. The mice were treated with intraperitoneal injection with DMSO or amlexanox (100 mg/kg) daily. The treatment started from the 7th day after implantation and lasted for ~21 days. (a) Representative images of bioluminescence of mice on days 7, 14, and 28 after implantation. (b) Quantitative analysis of these bioluminescence images for the DMSO and amlexanox treatment groups. (c) The overall survival of mice in the DMSO and amlexanox treatment groups. There was a substantial survival benefit for the amlexanox-treated mice. (d) Representative images of the HE and immunohistochemical staining for IKBKE and the Hippo pathway proteins in tumor sections (× 200 magnification). IKBKE protein was effectively inhibited by amlexanox treatment. Besides, the expressions of LATS2 and p-YAP1(Ser127) increased, whereas YAP1, Axl, c-Myc, Cyr61, MMP-2 and MMP-9 expression levels were simultaneously decreased in amlexanox-treated group relative to the DMSO-treated group. Data are shown as the mean±S.D. *P<0.05, **P<0.01 compared to the control (n=6)

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