Figure 1
From: TNFα deficiency results in increased IL-1β in an early onset of spontaneous murine colitis
Generation and characterization of the new TNFα KO Winnie murine model. (a) TNFα KO Winnie mice were generated by breeding double heterozygote breeders for TNFα and Winnie genes to obtain the double mutants and all the controls from the same breeding pair. All the resulting strains were viable and no significant variation from the predicted genotype was obtained in the 4-week-old offspring. (b) Weight analysis of 4-week-old mice from different genotypes reveals a significant decrease in body weight in mice carrying the Winnie mutation independently of the TNFα phenotype in both males and females. Statistical evaluation between C57/BL6 mice and each murine line was performed using unpaired two-tailed Student’s t-test. ***P<0.001, **P<0.01, *P<0.05
