Figure 4
From: TNFα deficiency results in increased IL-1β in an early onset of spontaneous murine colitis
Ileum homogenates show higher expression of NLRP3 and active form of caspase-1 in TNFα KO Winnie. Western blot analyses showed that the expression of NLRP3 (a) was higher in both Winnie and TNFα KO Winnie mice. Similarly, (b) the active form of caspase-1 (25 kDa) was significantly higher in both Winnie and TNFα KO Winnie mice. Quantitative data (bar graphs) were obtained by using ImageJ (NIH, USA) software. Statistical analysis was performed by using one-way ANOVA followed by Tukey’s multiple comparison as post-test. ***P<0.001, **P<0.01, *P<0.05
