Table 2 Anlysis of selected mRNA and protein expression alterations in the BRAFi-resistant cell lines compared with A375 parental cells

From: Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells

 

RNA

Protein

 

Genes

A375PR1

A375RV3

A375RV4

A375PR1

A375VR3

A375VR4

Protein

ALCAM

ND

ND

1.21

−0.15

0.83

1.23

CD166

ANPEP

ND

ND

3.8

1.88

1.96

2.73

CD13

CCND1

1

3.7

4.05

−0.3

1.02

1.28

CCND1

EFNA1

ND

ND

−0.45

−0.42

−1.17

−1.27

EFNA1*

EGFR

0.69

1.14

2

0.63

0.56

1.24

EGFR

EPHA2

1.32

2.77

3.29

0.46

1.86

2.3

EPHA2

FLI1

ND

ND

2.7

−1.16

0.79

1.61

FLI1*

MET

-0.07

0.5

0.88

1.08

0.89

1.28

MET

MITF

ND

ND

−2.43

−0.42

−1

−1.34

MITF

PTEN

ND

ND

ND

−1.19

−0.5

−0.48

PTEN

SOX10

ND

ND

−2.03

−0.36

−0.81

−1.13

SOX10

  1. A negative log2 value is indicative of downregulation and a positive log2 value shows upregulation of mRNA or protein expression*Measurement from immunoblotting
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