Figure 7
SDF1 partially rescues cardiac dysfunction induced by DOXO. Echocardiographic examination was performed on mice before (Day 0) and 21 days after the administration of DOXO (n=13), DOXO+SDF1 (n=13) or saline (n=13); (a) LV end-systolic volume (LVESV), (b) LV end-diastolic volume (LVEDV), (c) LV ejection fraction (LVEF), (d) LV anterior wall thickness at diastole (LVAWd). Evaluation of LV hemodynamic function with a Millar micro-tip catheter was performed at day 21; (e) LV systolic pressure (LVSP), (f) maximal rate of pressure development (+dP/dt) and maximal rate of pressure relaxation (-dP/dt). Saline, n=10; DOXO, n=10; DOXO+SDF1, n=13. Results are presented as mean±SD. (*P<0.05; **P<0.01; ***P<0.001)
