Figure 6
From: Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
USP5 is highly expressed in MM cells in association with c-Maf. (a) Expression of USP5 in primary MM bone marrow cells analyzed by DNA microarray. (1) Monoclonal gammopathy of undetermined significance; (2) Multiple myeloma; (3) Plasma cell leukemia; (4) Smoldering myeloma. (b) USP5 mRNA expression levels in normal bone marrow cells (NBM) and myeloma cells (MM). (c) the mRNA levels of USP5 and c-Maf in various MM cell lines assayed by RT-PCR. (d) USP5 and c-Maf protein expressions in various MM cell lines were evaluated by IB. (e) Cell lines with various origins were subjected to USP5 and c-Maf analysis
