Figure 8 | Cell Death & Disease

Figure 8

From: Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

Figure 8

Trehalose ameliorates OA in mouse DMM model. (a) Serum levels of trehalose in DMM mice treated with 2% or 5% trehalose. (b) Digital X-ray images of knee joints in four groups. Narrowing of joint space was indicated by white arrows, and the calcification of cartilage surface was indicated by black arrows. (c) Representative S-O staining of cartilage and H&E staining of synovitis in four groups at 8 week post-surgery (bar: 100 or 50 μm). (d) OARIS scores of cartilage and the scores of synovitis in four groups. (e) Immunohistochemical staining of 8-OHdG, p62, cleaved caspase 3, cytochrome C and CHOP and TUNEL staining in the mouse cartilage (bar: 50 μm). (f and g) Quantitation of immunohistochemical and TUNEL staining. All data represent mean±S.D. (n=5). ##P<0.01, versus Sham, **P<0.01, *P<0.05, versus DMM

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