Figure 10
From: Involvement of miR-451 in resistance to paclitaxel by regulating YWHAZ in breast cancer
Effect of miR-451 on tumor growth in xenograft model and in drug-resistant xenograft model. (a) Representative images of tumor growth at 4 weeks after injection using miR-451 antagomir or miR-451-NC antagomir in SKBR3 xenograft model, miR-451 agomir or miR-451-NC agomir in SKBR3/PR drug-resistant xenograft model, respectively. SKBR-3 in the left panel and SKBR-3/PR in the right panel injected in the mice. (b) The mean tumor weights were measured at 4 weeks post injection. *P<0.05; n=5. Mean±S.D. (c) Proliferative activity assessed by anti-PCNA and monoclonal antibody in the tumors, original magnification × 200. (d) TUNEL assay was performed to observe the apoptotic cells. Original magnification × 200. (e) Representative photos of mouse lungs and images of the histological inspection of mouse lungs for the presence of microscopic lesions, original magnification × 400. (f) Western blotting analysis was performed to detect the expression of β-catenin, c-Myc and cyclinD1 in vivo, β-actin served as a loading control
