Figure 7 | Cell Death & Disease

Figure 7

From: Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways

Figure 7

Induction of oncogenesis through inhibition of I-IFN synthesis by HCMV deubiqutinase (pUL48). Model showing the role of HCMV deubiquitinase in inhibiting I-IFN synthesis to promote oncogenesis. HCMV-DUB facilitates deubiquitination of TRAF6, TRAF3, IRAK1, IRF7 and STING to inhibit I-IFN synthesis, which in turn inhibits the expression of several pro-apoptotic genes and induces the expression of anti-apoptotic genes. Black arrows show normal cellular pathways. Maroon arrows show pathways during HCMV infection. Blunt arrows designate inhibitory action and pointed arrows designate stimulatory action. Red bubbles designate K63 ubiquitination of signaling molecules

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