Figure 3 | Cell Death & Disease

Figure 3

From: Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss

Figure 3

miR-34a modulates autophagy in HEI-OC1 cells. (a–c) Quantitative PCR (qPCR) analysis of miR-34a modulation of LC3B, p62. Date represent the mean±S.E.M. obtained from three independent experiments. (d) Western blot of LC3-II and p62 under various treatment with a miR-34a mimic (20 and 40 nM) or miR-34a mimic control. (e and f) Densitometry analysis of (d). (g) Western blot of LC3-II and p62 under various time after miR-34a mimic transfection. (h and i) Densitometry analysis of (g). *P<0.05. Date were represented as the mean±S.D. obtained from three independent experiments

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