Figure 3
From: The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma
HULC downregulation suppresses ovarian carcinoma cell proliferation, migration and invasion ability. QRT-PCR analysis indicated that HULC siRNA transfection reduced the expression of HULC (a). HULC downregulation by HULC siRNA transfection reduced cell proliferation compared with mock-transfected cells by RTCA (b), EDU (c) and cell cycle assay (d), while inducing cell apoptosis (e), 3-MA could reduce si-HULC’s function in inhibiting cell proliferation (f) and inducing cell apoptosis (g). HULC downregulation reduced cell migration (h) and invasion (i) ability compared with the control and mock-transfected cells. Results are representative of three separate experiments; data are expressed as the mean±S.D., *P<0.05
