Figure 1 | Cell Death & Disease

Figure 1

From: Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury

Figure 1

Neuron and microglia/macrophage-derived FGF10 increases with the activation of FGFR2/PI3K/Akt signaling after acute traumatic SCI. (a and b) Western blots and quantification data of FGF10 expression at several time points after acute SCI. (c-e) Double immunofluorescence of FGF10 and cellular markers for (c) neuron (NEUN) or (d) microglia/macrophages (Iba-1), in spinal cord tissue adjacent to lesion (scale bar: 50 μm). (e-g) Western blots and quantification data of FGFR2, p-Akt and Akt in each group at 1 day after surgery. (h) Double immunofluorescence of FGFR2 and NeuN in sections from tissue at 1 day after SCI (scale bar: 50 μm). Data represent the mean±S.D. Significant differences between the SCI and sham groups are indicated as *P<0.05, **P<0.01, ***P<0.001, n=5

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