Figure 7 | Cell Death & Disease

Figure 7

From: ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats

Figure 7

ANP promoted the expression of PCNA by activating AP1 in RU486-induced PCOS rats. PCOS rat model was established by RU486 treatment with or without ANP. (a) Representative images of immunohistochemical staining of PCNA and AP1 (p-c-Fos, p-c-Jun) in the ovarian granulosa cells (GC) of PCOS rats and ANP treatment group. Bar=20 μm. (b) Western blot analysis of PCNA and activation of AP1 in the ovary tissues of PCOS rats and ANP treatment group. The representative bands and statistical analysis were shown. Significance was indicated by *P<0.05, **P<0.01

Back to article page