Figure 1
From: Alternative mechanisms of miR-34a regulation in cancer
Feedback regulation of miR-34a. Upon DNA damage, miR-34a transcription is induced by p53. miR-34a targets p53 directly by interaction with its transcript and indirectly through targeting of p53 inhibitor MDMX (yellow). MiR-34a-mediated inhibition of p53 deacetylase SIRT1 is implicated in apoptosis (green). Feedback inhibition between miR-34a, IL-6R and P-STAT3 is implicated in inflammation, while regulation of PD-L1 – P-Akt axis is important for immune surveillance (red). In EMT, miR-34a is implicated in multiple feedbacks encompassing EMT regulators Snail, ZEB1 or AXL (blue)
