Table 2 Outcomes of miR-34a modulation in models lacking p53 expression due to genomic deletion
From: Alternative mechanisms of miR-34a regulation in cancer
Cancer type | Target cells | Type of miR-34a modulation | Outcome | Reference |
|---|---|---|---|---|
Lung cancer | H1299 | Inducible overexpression | Inhibition of migration and invasion | |
H1299 | Transfection of expression plasmid | Inhibition of colony formation, induction of apoptosis | ||
H1299 | Introduction of miRNA precursor | Suppressed DNA repair after irradiation, sensitization to radiotherapy in xenograft tumors | 115 | |
H1299 | Liposomal in vivo delivery of mature miRNA | Downregulation of immune-suppressive PDL-1, prevention of immune evasion | ||
H358 | Introduction of synthetic miRNA oligos | Potentiation of the effect of EGFR inhibition | ||
Breast cancer | 4T1 | Introduction of miRNA precursor | Decreased tumor growth and Treg recruitment | |
Prostate cancer | PC3 | Introduction of miRNA precursor | Cell growth inhibition, chemosensitization to camptothecin | 116 |
PC3 | Introduction of synthetic miRNA oligos | Inhibition of cell proliferation, induction of apoptosis | ||
PC3 - taxane resistant | Rubone-induced stabilization combined with paclitaxel | Inhibition of tumor growth, decreased cell viability | 113 | |
Gastric cancer | Kato-III | Introduction of miRNA mimics | Growth arrest, chemosensitization and apoptosis | 117 |
Myeloid leukemia | HL-60 | Introduction of miRNA precursors/inhibitor | Reduction/restoration of PD-L1 expression and PD-L1 specific T cell apoptosis |
