Figure 8
From: Overactive type 2 cannabinoid receptor induces meiosis in fetal gonads and impairs ovarian reserve
Schematic representation of the effects of CB2R overactivation on fetal ovary. Pregnant females were intraperitoneally injected with JWH133 for 4 consecutive days at the onset of meiosis in oocytes (E12.5). Morphological analysis of F1 ovary at birth (1 dpn) showed a reduced number of primordial (Pr) and primary (Pry) follicles with respect to control. F1 JWH133 female crossed with untreated male showed a decreased fertility with a smaller litter size at F2
