Figure 2
From: Current progress in the derivation and therapeutic application of neural stem cells
Sources of NSCs. Using recent technical advances, NSCs can be derived via three diverse methods: direct extraction from primary CNS tissues, including fetal brain, adult brain and spinal cord tissue; differentiation from pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells; and transdifferentiation from somatic cells, such as skin fibroblasts, urine cells and blood cells, which are easily harvested in the clinic. NSCs generated from the above sources can be further immortalized via genetic modification
