Figure 1 | Cell Death & Disease

Figure 1

From: CITED2 affects leukemic cell survival by interfering with p53 activation

Figure 1

Knockdown of CITED2 in AML cells impairs leukemia development. (a) Schematic overview of lentiviral shRNA transductions for mice transplantation experiments. (b) Kaplan–Meier curve indicating the survival of mice transplanted with sorted control- or shCITED2- transduced CD3-depleted AML cells. n=4, P<0.02. (c) NSG mice were analyzed for the presence of human engraftment at indicated time points after transplantation with control- or shCITED2-transduced AML cells. Percentage of human CD45+ cells in peripheral blood is shown. Survival of the individual mice is indicated in brackets. (d) FACS plots indicating sorting strategy for human GFP+ cells from sacrificed NSG mice (left panel) and Q-PCR analysis for CITED2 in sorted cells (right panel) are shown. Error bars indicate s.d. of Q-PCR triplicates

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