Figure 8
From: PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC
The schematic representation of the regulatory mechanism about PLOD2 was summarized. (a) The schematic representation of the regulatory mechanism about PLOD2 was summarized based on this study. PLOD2 can be regulated by transcription factor FOXA1 via the phosphatidylinositol-3-kinase/AKT (PI3K/AKT) signaling pathway. Meanwhile, PLOD2 promotes NSCLC metastasis directly by enhancing migration and indirectly by inducing collagen reorganization. (b) The schematic representation of PLOD2 is summarized based on previous reports of the regulatory mechanism and this study. Previous reports showed that PLOD2 could be regulated by tumor growth factor-α (TGF-β) and hypoxia-inducible factor-1α (HIF-1α), whereas TGF-β and HIF-1α can also activate the PI3K/AKT signaling pathway. Therefore, it is suggested that PLOD2 may be a potential therapeutic target that can be regulated by several oncogenes via PI3K/AKT signaling pathway
