Figure 9 | Cell Death & Disease

Figure 9

From: Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity

Figure 9

Effects of XIAP deletion in l-arginine-induced pancreatitis. Results demonstrate a marked reduced necrosis in XIAP−/− mice on hematoxylin and eosin staining (a and c), while an increase in acinar cell apoptosis in XIAP−/− mice on TUNEL assay (b and d), as compared with wild-type mice treated with l-arginine. Bar indicates 50 μm. Arrow shows typical signs of pancreatic pathology (a) and the positive staining of death cell (b). Moreover, serum amylase (e) was significantly decreased in XIAP−/− mice, as compared with wild-type mice. Controls were injected with saline alone for wild-type mice and XIAP−/− mice. Results are expressed as means with the S.E.M. of at least three separate experiments with statistical significance at *P<0.05

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